In November 2019, City Football Group agreed a deal to acquire a majority stake in Mumbai City FC in the Indian Super League, marking a major move into Indian football.

In 2021 Mumbai City FC were crowned Champions of the Hero Indian Super League after a 2-1 win over ATK Mohun Bagan at the Fatorda Stadium in Goa. 

Mumbai City FC's victory saw them become the first team in ISL history to secure both the ISL Shield and the ISL Trophy, completing a double in the same season. 

In 2022, the Club played its first game in the AFC Champions League, and in April became the first Indian football club to win a match in the competition. 

The Club plays its home games at the 8,000 capacity Mumbai Football Arena, which sits within the Andheri Sports Complex, a multi-purpose sports facility.